The M62 was closed in both directions between junctions 22 and 24 as a result of the incidents.
West Yorkshire Police have confirmed two people died in two incidents on the M62 on Wednesday morning.
Officers were called to the exit slip road of the eastbound carriageway at junction 24 at 1am following a collision involving a motorcyclist and another, stationary, vehicle.
The 50-year-old motorcyclist died as a result of the accident.
Then at 5am police were called to reports of a man sighted on Scammonden Bridge, which runs over the M62. The man fell from the bridge at around 6am and died as result of his injuries.
West Yorkshire Police has referred itself to the Independent Office for Police Conduct.
The M62 was closed in both directions between junctions 22 and 24 as a result of the incidents and motorists caught up in traffic delays have been praised by for their patience.
Detective Superintendent Jim Griffiths of the Major Collision Enquiry Team (MCET), said: “The two incidents meant there was a significant impact on the road network – especially for motorists looking to get to work in and around ‘rush hour’.
“I appreciate that the closures caused significant disruption but they were necessary to allow the emergency services to go about their work. Any decision to close the motorway is not taken lightly and the road has now reopened.
“I would like to thank motorists who were caught up in the traffic for their patience and understanding as we worked to investigate what had happened and to get the road reopened.”
The carriageway is now fully open.